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However, members of the PDE superfamily share a highly conserved catalytic domain, and the individual PDE isoforms diverge substantially in their substrate preferences, regulatory mechanisms, and regional expression patterns, which together influence their therapeutic relevance

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These adjustments should follow standard escalation timing rather than impulsive changes

doi: 10.1186/PREACCEPT-1843684980131041 8 LimE-JSonC-G