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April 20, 2024
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In summary, melanin pigmentation may be physiologic or pathologic, and may clinically present with focal, multifocal, or diffuse patterns
Patients without Neurofibromatosis type 1 (NF1) tend to have better outcomes than those with NF1-associated MPNST, as NF1-related tumors are more likely to be multifocal, high-grade, and resistant to therapy (Evans et al., 2021)
It also slows gastric emptying and reduces glucose production by the liver
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