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Its worth noting that stopping GLP-1 therapy entirely can lead to weight regain
Decision framework: Start existing treatments (semaglutide or tirzepatide) if: Your health risks from obesity are significant and immediate (uncontrolled diabetes, severe sleep apnea, cardiovascular disease) You have access to approved therapies through insurance or can afford them You need proven, FDA-approved medications with established safety profiles Waiting 1-2+ years for retatrutide approval doesnt align with your health timeline Consider waiting if: Youre currently at a stable weight with controlled health conditions Youve tried semaglutide or tirzepatide and hit a plateau but tolerated them well Youre in a position to potentially enroll in a retatrutide clinical trial You understand waiting means continued health risks from obesity Dont wait if: You think retatrutide will be a magic bullet with no downsides Your doctor is recommending treatment now for medical reasons Youre using waiting for the next best thing as an excuse to avoid addressing the problem The lifestyle component is non-negotiable regardless of which medication you use: High protein intake (0.7-1g per pound of body weight daily) to preserve muscle during weight loss
In the Middle East, a study performed in Saudi Arabia reported that in patients with type 2 DM, the prevalence of DPN assessed by the Michigan Neuropathy Screening Instrument (MNSI) is 27.7% (30)
GLP1RAs have indeed revolutionized the landscape, with the availability of formulations that are conveniently administered in daily or weekly doses
He pointed to CVS Caremarks recent change
