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Nevertheless, any significant changes in mood or sleep patterns should be reported to healthcare professionals
Owing to the heterogeneous nature of the disease, these patients usually encounter difficulties in their treatment course
Furthermore, impaired GH secretion in these individuals is linked to a reduction in visceral fat and elevated ghrelin concentrations relative to the degree of obesity (110)
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Approximately 10% of energy-controlling gene expression, including those encoding nuclear hormone receptors and glucose and lipid metabolism enzymes, are regulated by circadian rhythm in a tissue-specific manner (Storch et al., 2002
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