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Oxidative stress occurs when reactive oxygen species exceed the bodys ability to regulate them through antioxidant systems
It is the only PDE with Ca 2+ -mediated stimulation through calmodulin and is distinctively aligned to facilitate the crosstalk between calcium and cAMP/cGMP cascades (Hayes et al., 2021)
Oxidative stress induces tissue damage through free radical generation and profound lipid peroxidation, as demonstrated by increasing MDA [31]
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