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Energy yield and you can lose more weight by exercising
Common side effects of sitagliptin include: Diarrhea Headache Nausea Sore throat Stuffy or runny nose Swelling of hands or legs Upper respiratory infection Serious sitagliptin side effects include: Allergic reactions (hives, difficulty breathing or swelling of the lips, face, tongue or throat) Heart failure (rapid increase in weight, shortness of breath or swelling of the feet) Hypoglycemia (low blood sugar) Necrotizing pancreatitis (a complication of acute pancreatitis that causes tissue death) Acute pancreatitis (inflammation in the pancreas, causing abdominal pain) Severe joint pain Severe skin reaction (rash, blistering or peeling, burning eyes or facial swelling) Increased blood glucose, pancreatitis, pancreatic cancer and gastrointestinal disorders (vomiting, diarrhea and nausea) were the most commonly reported side effects of Januvia and Janumet to the FDAs Adverse Event Reporting System (FAERS)
J Clin Exp Dent
A recent BMJ editorial, Malnutrition with use of GLP-1 agonists is an underestimated real world harm, highlights how these therapies can cause unintended nutritional consequences that remain poorly recognised in practice (BMJ 2025)
While there are no approved indications for using GLP-1 agonists specifically for the treatment of lipedema, these medications have shown numerous health benefits for women with dozens of medical conditions, such as Diabetes, Heart Disease, Kidney Disease, Parkinsons Disease, and Obesity, as well as for women without any existing medical problems
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