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Clin Exp Nephrol 19(3):331335
In patients with type 2 diabetes, the mean population-PK estimated steady-state concentrations following once-weekly subcutaneous administration of 0.5 mg and 1 mg semaglutide were approximately 65 ng/mL and 123 ng/mL, respectively
Patients normally begin the medication at a low dose and then the dose is gradually increased until it reaches the maximum
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It has never been FDA-approved and has less published human clinical data than MK-677 or CJC-1295
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