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Large-scale, randomized controlled trials are critically needed to establish definitive efficacy for specific clinical indications and to compare these peptides with established therapies
IGF-1 binds to receptors on muscle cells and promotes cell growth and division through autocrine signaling
Drugs 83 , 265273 (2023)
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Overall, constitutive autophagy maintains cardiomyocyte size, architecture, and basal performance in the healthy heart, whereas in failing myocardium, enhanced autophagy functions predominantly as a compensatory survival mechanism
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