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Systemic exenatide treatment can reverse aging-associated transcriptomic changes in various brain cell types in mice, including glial and neurovascular cells
73.5% reached HbA1c 6.5% vs 15.9% placebo
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Mood symptoms Animal studies, case reports, and a meta-analysis of RCTs of GLP-1 RAs suggest that these medications might help with depression (Chen X et al, Am J Geriatr Psychiatry 2024;32(1):117127)
For a 5-day burst, most metabolic effects resolve within 7 to 14 days
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