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As an example, it showed protection against oxidative stress induced by Cyclosporine-A by scavenging most radical species, measured by the increase of GSH/GSSG ratio and the decrease of lipid peroxidation levels in tubular cells in rats ( in vivo study with HOTYR (250 and 500 mg/kg/day) markedly inhibited the growth of cholangio-carcinoma xenografts in mice, through G2/M phase cell cycle arrest and apoptosis ( Epidemiological studies have suggested that HOTYR may have protective effects against several types of cancer ( As shown, most studies to date have been investigated in cell lines and a relative few number of studies are in animals or human beings
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