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As the field matured, concern emerged that ovarian epimerase overactivity in PCOS shifts local MI to DCI, creating an ovarian paradox
While there can be a number of mostly gastro-intestinal side-effects from Tirzepatide and others (acid reflux, burping, constipation, nausea) by starting at a really low dose, increasing slowly and not going too high on the dose most of these types of side-effects can be minimized
After finding Ozempic ineffective, the 50-year-old Spelling gave the other GLP-1 a whirl and succeeded in losing weight
Similar restrictions apply to liraglutide (Saxenda) under NICE TA664
The cost can vary significantly depending on the treatment selected
