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The B12 emollient produced greater reductions in lesion severity and extent (Del Duca 2017)
Animal studies support this, with effective doses in rats being considerably higher on a weight basis than typical human doses, raising the possibility that some clinical trials may have used subtherapeutic dosing
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[3] [4] Based on Phase 2 clinical trial data published in the New England Journal of Medicine in 2023 covering both obesity and type 2 diabetes populations retatrutide was administered as a once-weekly subcutaneous injection within those trial protocols
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