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K.MartnekJ.HornekA.KmonckovE.ZdekZ.et al (2009)
It is rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4) the same enzyme that degrades GLP-1
Specifically in colon cancer and prostate cancer, exendin-4 increased intracellular cAMP levels while inhibiting glycogen synthase kinase 3 and ERK-MAPK activation, leading to an increase in apoptosis [93]
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