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The defining 2018 Biochemical Pharmacology study reported a methylquinolinium NNMT inhibitor reducing body weight, white-fat mass and adipocyte size in diet-induced obese mice without changing food intake, while raising intracellular NAD+ and SAM [1]
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Preclinical studies suggest this inhibition may protect against diet-induced weight gain and improve metabolic health
Furthermore, research published in the journal Obesity Science & Practice highlighted the benefits of semaglutide for long-term weight maintenance, demonstrating sustained reductions in body weight and improvements in obesity-related comorbidities over time
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