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This substantial deacetylation is the reason that high plasma levels of acetyl-l-carnitine are not observed after its oral intake, unlike after parenteral administration, during which the substance bypasses the gut and enters the bloodstream directly

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In 1857, Virchow formally put forward the concept of melanosis coli.7 MC is becoming increasingly common because there are many pathological conditions of the bowel that prompt the use of anthraquinone laxatives.8 To promote a better understanding of MC, we will summarize the recent progress made in MC research