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Since the human genome contains only one glutathione synthetase gene, the various clinical forms of glutathione synthetase deficiency reflect different mutations or epigenetic modifications in the glutathione synthetase gene
Acessado em 29 de maro de 2024
doi:10.1093/carcin/bgs006, PMID: 22235026 Wachsman JT (1997) DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis
The ubiquitination-26S proteasome system is a key pathway for protein degradation, involving a cascade reaction catalysed by specific enzymes: ubiquitin-activating enzyme (E1), ubiquitin-binding enzyme (E2), and ubiquitin ligase (E3), with the substrate primarily dictated by ubiquitin ligase 40,41,42
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