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The STEP (Semaglutide Treatment Effect in People with obesity) 1 trial was a randomized, placebo-controlled trial that evaluated the efficacy of once-weekly subcutaneous (SC) semaglutide 2.4 mg plus lifestyle interventions in adults with obesity without diabetes (n = 1961)
OR 2 = 0.95 [95% CI 0.920.99], P 2 = 1.71 10 2 )
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In animal models, semaglutide reduces food intake and body weight by activating Adcyap1-expressing neurons in the dorsal vagal complex, a key integrator of gutbrain signals that induce a reduction in food intake via both homeostatic and hedonic pathways [78]
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