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These side effects are usually not too serious and can often be managed by adjusting the dose or taking the medicine with food

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Low-grade inflammation due to exaggeration of inflammatory signaling pathways and increasing the release of pro-inflammatory cytokines, mainly IL-1, IL-6, and TNF- induce brain leptin resistance in obesity (Paz-Filho et al

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While they both work on the GLP-1 hormone, semaglutide and tirzepatide differ in three key ways: Their mechanism of action (aka how they work) The specific conditions theyre approved to treat Their effectiveness at treating those conditions The forms in which theyre available ( oral semaglutide is also available for diabetes and for weight loss) Lets start by reviewing their mechanism of action (how they work)