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Whilst metreleptin monotherapy supports weight loss in obese individuals, it is not clinically meaningful with a mean 1.5 kg additional weight loss over 24 weeks noted in a previous trial [87]

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Symptomatic treatment Severe GI adverse reactions require doctor-supervised antiemetic or antidiarrheal medication

Available from Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration

Adems, en el mismo trabajo, menos pacientes en el grupo de liraglutida presentaron progresin de fibrosis comparado con el placebo, sin diferencias en la inflamacin lobular ni en el puntaje general de actividad de NAFLD20