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Similar concerns apply to phosphodiesterase-5 inhibitors (medications like sildenafil) and L-arginine supplements that also influence nitric oxide signaling

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Avoid these medications if: You or a family member has a history of medullary thyroid cancer (MTC) or MEN2 syndrome Youve had a serious allergic reaction to GLP-1 medications in the past You are pregnant or planning pregnancy You are currently on another GLP-1 medication or insulin You have severe gastrointestinal issues , pancreatitis, or advanced kidney/liver problems Youre experiencing significant mental health changes (depression or suicidal thoughts) You are breastfeeding , as it's unknown if the medication passes through breast milk What About Cost & Insurance