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Rotenone increased microglial activation in both the SNpc and striatum in rats (Sherer et al., 2003a), activated microglia via the NF-B signaling pathway (Gao et al., 2013) and induced neuronal death by the microglial phagocytosis of neurons (Emmrich et al., 2013)

however, since then, four states (California, New Hampshire, Pennsylvania, and South Carolina) have eliminated coverage of GLP-1s for obesity treatment, likely reflecting recent state budget challenges and the significant costs associated with coverage

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