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Fras JP, Auerbach P, Bajaj HS et al (2021) Efficacy and safety of once-weekly semaglutide 20 mg versus 10 mg in patients with type 2 diabetes (SUSTAIN FORTE): a double-blind, randomised, phase 3B trial
Diabetes Ther 16 , 813849 (2025)
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Specific digestive enzymes, most notably gamma-glutamyltransferase (GGT) and various intestinal peptidases, cleave the tripeptide into its constituent amino acids long before it can reach systemic circulation intact
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