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Although NNMT may affect nicotinamide levels and NAD+ pathways, the real impact in the body is still unclear
the clinical relevance of this finding in humans is unknown, and in UK and EU prescribing information this is noted as a precaution rather than a formal contraindication but individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) should discuss this with their doctor
While supplements are usually given as tablets, your doctor may recommend B12 injections, depending on your situation
According to NICE Clinical Knowledge Summary guidance, patients with neurological involvement should receive more intensive initial treatment to optimise recovery potential
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