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Description

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Elevated cAMP levels stimulate protein kinase A (PKA), which phosphorylates target proteins and inhibits myosin light chain kinase (MLCK), resulting in relaxation of bronchial smooth muscle and bronchodilation

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The included trials were those with administration of recombinant semaglutide in which PK samples, assessed via liquid chromatography and tandem mass spectrometry (LCMS/MS) [3], were available at the time of the analysis

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