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GHD also contributes to the alteration of body composition and weight gain, with decreased lean mass, increased FM, mainly truncal FM with increase waist/hip ratio, scarce muscle tone and strength, reduced energy expenditure, and exercise tolerance [45,46,47]

Glucagon-like peptide-1 (GLP-1) receptor agonists represent a class of medications increasingly prescribed for type 2 diabetes management and, more recently, for chronic weight management

Historical Background and Scientific Context Scientific interest in synthetic peptides expanded substantially as advances in analytical chemistry and peptide synthesis enabled researchers to investigate increasingly complex molecular communication systems

Some research suggests berberine may support the release of GLP-1 by stimulating bitter receptors in the gut

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