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Subsequently, for these data as well as the alpha diversity analyses, each treatment group (within each phylum or genus for the relative abundance data) was analyzed for normal distribution (ShapiroWilk test) and the data across groups were tested for homoscedasticity (BrownForsythe test)

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However, headache incidence rates were similar between AOD-9604 and placebo groups, suggesting that many cases represented background occurrence rather than treatment-related effects

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