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Nevertheless, when the two drugs were directly compared in a randomized trial for improving glucose regulation, tirzepatide was superior to semaglutide, as shown below
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While sore throat is unlikely to be directly caused by tirzepatide, certain presentations warrant prompt medical evaluation
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While activating ARC AgRP/NPY neurons has been shown to be both aversive [136] and rewarding [144] depending on the duration of activation, the positive valence associated with inhibiting ARC AgRP/NPY neurons [136] lends itself well to targeting these neurons for obesity drug development
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