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Recommended High Dosage Glutathione Amounts The ideal glutathione dose depends on your goals and experience methods: Low to moderate doses (500mg-1500mg): gentle daily upkeep, slow changes Mid-range doses (1500mg-5000mg): visible skin changes, more antioxidant benefits High dose (5000mg+): intensive approach - usually seen in IV therapy for quicker impact It is recommended to start with a lower glutathione dose and increase gradually