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This is particularly concerning for patients who had significant cardiovascular risk reduction during treatment

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What to Expect: GLP-1 Side Effect Reality Check Nausea : The most frequently reported side effect, typically more prominent when first starting or increasing doses Vomiting : Less common than nausea, possible during initial adjustment Diarrhea or constipation : Can occur alongside other GI effects Reduced appetite : A therapeutic effect that helps with weight loss, but can sometimes feel uncomfortable Many patients report that side effects decrease significantly after the first few weeks, and severe reactions requiring discontinuation are relatively rare