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Efflux regulators also respond to endogenous ligands (eg, AcrR responds to polyamines) to induce acrAB-tolC
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While this mechanism prevents premature cell death, it simultaneously promotes the accumulation of damaged and dysfunctional cells, which disrupt tissue homeostasis and contribute to the progression of age-related diseases
With the progression in the field of steroid research and their mechanism of action, several steroid and non-steroid GC analogues with decreased adverse effects were developed for potential treatment on cancer, inflammatory and autoimmune diseases
Together they target four receptor pathways
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