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Central angiotensin-IV binding-sitesdistribution and specificity in Guinea-Pig brain

The confirmatory secondary endpoints included the change in the 6-min walking distance, a hierarchical composite of death and heart failure events

Biological activity duration: Despite the short plasma half-life, downstream effects on telomerase expression and pineal regulation persist substantially longer (days to weeks) consistent with Epithalon acting as a signaling molecule triggering longer-lived transcriptional changes rather than direct dose-response activity