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The research supports both approaches depending on what you are optimizing for
doi:10.1210/jc.2006-1702 Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Peitra C
This dose keeps vitamin B12 levels normal and stops deficiency symptoms from coming back
As well as targeting GLP-1 and GIP receptors, which other treatments like Mounjaro do, Retatrutide also works on glucagon receptors (GCG). Activating glucagon receptors encourages your body to burn more calories, which can help you reach a calorie deficit faster
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