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Pironi et al., 1993
1 Carmot Therapeutics, a member of the Roche Group, Berkeley, CA, USA, 2 Avant Sant, San Pedro, Mexico, 3 Syneos Health, Adelaide, Australia
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However, additional therapies are required to circumvent rate-limiting steps within the signalling pathways of insulin action or to intervene directly in cellular glucose metabolism to reduce excess glucose production, improve peripheral glucose disposal and reduce glucotoxicity
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