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While the classical incretin concept is based on the assumption that incretin hormones such as GIP and GLP-1 reach their main endocrine target cells via the bloodstream, there is some evidence that GIP (and possibly GLP-1) can be produced in relatively small amounts in endocrine alpha-cells of the pancreas [3]
The presence of glutamate receptors has been demonstrated to be important for the response to ingested glutamate in mice [31]
doi: 10.3168/jds.2015-10525 Summary Keywords bovine, bypass amino acid, epigenetic, fetal programming, immune system, N retention, performance, reproduction Citation Costa TC, Nascimento KB, Dans MAC, Gionbelli MP and Duarte MS (2025) Rumen-protected methionine for dairy and beef cattle: current perspectives on methionine role, supplementation strategies, metabolism, health, and performance
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