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Similarly, although SDF-1 may ameliorate kidney injury and promote repair after nondiabetic ischemia [26], potentiation of the chemokine can contribute to a proliferative response that leads to glomerulosclerosis, podocyte loss, and albuminuria [27, 28], thus implicating SDF-1 in the pathogenesis of diabetic nephropathy
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Our risk for these other conditions increase based on how much excess weight someone carries and how long they carry it
Their most advanced oral program is orforglipron, a small-molecule GLP-1 receptor agonist that, unlike tirzepatide, is not a peptide and therefore does not face the same bioavailability challenges when taken orally
Noh HS, Kim YS, Kim YH, Han JY, Park CH, Kang AK, et al
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