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Researchers planning new work should review the most current literature directly, with attention to the gap between the older sleep claims and the open mechanistic questions

It adversely affects brain homeostasis through BBB dysfunction and hyperthermia ( Various METH dosing paradigms significantly disturb endothelial TJ assembly by inducing downregulation, fragmentation, or redistribution of major TJ proteins, including claudin-5 and ZO-1, which are mediated by MMP-1 and MMP-9 peptidases

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