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This constant state of poor sleep increases the body's overall stress load and can lead to cortisol dysregulation, which further compounds exhaustion and perpetuates the fatigue cycle
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Treatment of Otsuka Long Evans Tokushima Fatty (OLETF) rats, an obese animal model of type 2 diabetes, with the PPAR agonist fenofibrate reduced the decline in beta cell mass and prevented the development of diabetes [23]
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