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This selectivity occurs because AOD-9604 does not bind to growth hormone receptors in muscle tissue and works primarily through beta-3 adrenergic receptors that are predominantly expressed in fat cells

Animal experimental evidence Osteoclast precursor (RAW264.7) experiment: AOD 9604 significantly inhibited RANKL induced osteoclast formation, reduced the number of TRAP positive multinucleated cells, and decreased bone resorption pit formation

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