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Reconstituted Material: Once reconstituted, researchers generally store solutions under refrigerated conditions and utilise them within suitable laboratory timeframes

Semaglutide dosing Starts at 0.25 mg/week, increasing by 0.250.5 mg every 4 weeks up to a 2.4 mg/week maintenance dose, injected once weekly

However, GLP-1 pricing complexity arises because medication efficacy varies widely: a lower-cost tier may require dose escalation or medication switching within months, negating initial savings

Notably, after 43 days of treatment, significant reductions in AUC were observed in all groups receiving GLP-1 receptor agonists, indicating improved glycemic control ( Figure S4B , D , Method S3 )

To address missing laboratory data (e.g., BMI, HbA1c, SBP, lipids, and UPCR), we included a distinct no measurement category for each variable in the propensity score model