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The same criteria were applied to obtain the gene list for either activated or repressed by LAG-1 in the time course RNA-seq analysis

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Safety Profile The safety profile of the triple agonist class is consistent with the known GLP-1R agonist class profile, with gastrointestinal adverse events (nausea, vomiting, diarrhea, constipation) being the most frequently reported and typically most prominent during dose escalation before diminishing with continued administration

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