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Both corticosteroids and NSAIDs have been found to cause gastrointestinal injury through multiple mechanisms, including direct irritant effects on the protective layer of the GI tract, impairment of protective mechanisms such as suppression of gastric prostaglandin production, and reduced blood flow which interferes with the bodys repair response

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PMID 11665618

Peptides with human exposure or limited clinical studies, but no established benefit for the uses now being marketed