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Ischemia-induced endothelial cell activation, expression of adhesion molecules (P-selectin, ICAM-1), and reperfusion-associated ROS production promote leukocyte-endothelial adhesion, capillary plugging, and endothelial barrier dysfunction

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Diabetes constituted the majority of indications (n = 16,863, 58.2%), followed by weight control (n = 1,352, 4.7%) and non-diabetic blood glucose abnormalities (n = 556, 1.9%)

By 2050, the Alzheimers Association estimates that number may grow to 12.7 million unless something changes drastically