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While this strategy improves the precision of estimatesparticularly for subgroupsit tends to reduce the overall response rate
A clinical trial is a study designed to determine whether a new medicine is safe and effective
Many foundational studies involved small numbers of subjects, appropriate for mechanistic pharmacology but insufficient for efficacy or safety conclusions
Remarkably, analysis of the single-cell RNA sequencing data set CD patients revealed metabolic changes and signs of mitochondrial stress signaling as well as changes in epithelial subtype composition even in mucosal tissues that were considered non-inflamed by endoscopy
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