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281 Importantly, while acute or overwhelming endoplasmic reticulum stress can induce cell death, chronic UPR activation favors drug tolerance and persistence, positioning endoplasmic reticulum stress adaptation as a systems-level resistance mechanism complementary to oncogenic signaling network adaptation

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164 The NAD + /SIRT1 signaling pathway functions as a central node linking nutrient sensing, autophagy regulation, and ER adaptation

RSC Adv 12:1802218038

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