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Additionally, lixisenatide was associated with fewer gastrointestinal symptoms compared to exenatide, while long-acting GLP-1RAs generally caused less nausea and vomiting but more diarrhea than short-acting agents (49)

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Self-monitoring of blood glucose is particularly important for patients on concomitant insulin or sulfonylureas, as GLP-1 therapy may necessitate dose reductions of these medications to prevent hypoglycemia

Comprehending the array of potential adverse reactions and contraindications related to the usage of GLP-1 agonists is critical both for practitioners administering care and patients receiving treatment so that they make informed decisions regarding safe usage while factoring in patient preferences alongside each drugs unique profile balancing risks against benefits