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Inflammasome activation, macrophage infiltration, and cytokine production have been documented in cystinosis, indicating that chronic inflammation plays a key role in disease pathogenesis [147]
BPC-157, TB-500 and GHK-Cu are used in in-vitro systems, ex-vivo tissue explants and animal models to study endpoints such as endothelial-cell activity in angiogenesis assays, fibroblast-associated matrix gene expression, cell migration and wound closure
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