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In this double-blind trial of 1,961 adults with a body mass index (BMI) of 30 or higher, adults on high dose 2.4 mg of weekly semaglutide (compared with the usual type 2 diabetes dose of 0.5mg or 1mg) lost an average 14.9% of baseline body weight after 68 weeks of treatment versus only 2.4% for a group on placebo and lifestyle intervention alone

Expert Opinions: Medical experts and endocrinologists have voiced cautious optimism about the potential synergies between semaglutide and the ketogenic diet for weight loss and diabetes management

These reactions are generally mild, self-limiting, and resolve within a few days without intervention

Taking it more frequently would lead to dangerous accumulation

More recently, GLP-1s have been designed to target obesity, too