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Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics
LAG-3 and PD-1 synergize on CD8(+) T cells to drive T cell exhaustion and hinder autocrine IFN-gamma-dependent anti-tumor immunity
These observations are drawn from cell-culture and animal-model systems and are reported here strictly as research findings, not as characterizations of effects in humans
Free Radical Biology & Medicine, 19(2), 227-250
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