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Tirzepatide, on the other hand, is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, targeting two hormones to improve blood sugar control and weight loss more effectively

In addition, fifty-one of fifty-nine included studies (864%) conducted at least one method of formal pleiotropy assessment (MR-Egger test, MR-PRESSO outlier tests or leave-one-out analyses) and only eight studies reported no formal pleiotropy assessment (Table 2)

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