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doi:10.1007/s00404-024-07849-9 Ivanisevic M, Herman M, Horvaticek M, Vucic Lovrencic M, Delmis J

Cellular stress, often observed in the autistic brain [158], activates p53, which inhibits the activity of mTORC1 via AMPK and TSC2 activation [303]

It is important to recognise that: Living with type 2 diabetes itself carries an increased risk of depression and anxiety Significant weight loss, whilst often beneficial, can sometimes trigger unexpected emotional responses Changes in eating patterns and blood sugar fluctuations may affect mood stability The burden of managing a chronic condition can contribute to psychological distress Warning signs that warrant attention include persistent sadness lasting more than two weeks, loss of interest in previously enjoyed activities, significant changes in sleep or appetite, difficulty concentrating, feelings of worthlessness, or thoughts of self-harm

Front Physiol (2019) 10:866